$$3\times 2s^{3-1}-2\left(-4\right)s^{-2-1}-8\times 8s^{-8-1}$$
Multiply $3$ times $2$.$$6s^{3-1}-2\left(-4\right)s^{-2-1}-8\times 8s^{-8-1}$$
Subtract $1$ from $3$.$$6s^{2}-2\left(-4\right)s^{-2-1}-8\times 8s^{-8-1}$$
Multiply $-2$ times $-4$.$$6s^{2}+8s^{-2-1}-8\times 8s^{-8-1}$$
Subtract $1$ from $-2$.$$6s^{2}+8s^{-3}-8\times 8s^{-8-1}$$
Multiply $-2$ times $-4$.$$6s^{2}+8s^{-3}-64s^{-8-1}$$
Subtract $1$ from $-8$.$$6s^{2}+8s^{-3}-64s^{-9}$$