$\left( -6{p}^{3}{x}^{2} \right) \times \left( 8{y}^{3}{x}^{2} \right)$
Use the commutative property to reorder the terms$\left( -6{p}^{3}{x}^{2} \right) \times \left( 8{x}^{2}{y}^{3} \right)$
Multiplying a negative and a positive equals a negative: $\left( - \right) \times \left( + \right)=\left( - \right)$$-6{p}^{3}{x}^{2} \times 8{x}^{2}{y}^{3}$
Calculate the product$-48{p}^{3}{x}^{4}{y}^{3}$