$\frac{ pq{r}^{3} }{ -6 \times {\left( qr \right)}^{2} }$
To raise a product to a power, raise each factor to that power$\frac{ pq{r}^{3} }{ -6{q}^{2}{r}^{2} }$
Simplify the expression$\frac{ pqr }{ -6{q}^{2} }$
Cancel out the common factor $q$$\frac{ pr }{ -6q }$
Use $\frac{ -a }{ b }=\frac{ a }{ -b }=-\frac{ a }{ b }$ to rewrite the fraction$-\frac{ pr }{ 6q }$